Junior Haley Fowler scored 27 points and grabbed 14 rebounds as defending state champion Smyer defeated Martin's Mill 52-49 in a re-match of the 2010 finals.
Fowler scored 11 of her points in the deciding fourth quarter that saw the Lady Cats (35-2) rally from a 43-42 deficit with 2:59 left.
Fowler was named the championship game's MVP for the second straight state tournament.
Smyer sophomore Kennedy Farr added 17 points and six rebounds. Farr and Fowler combined for 44 points, 28 in the paint.
Hailey Jenkins of Martin's Mill (39-4) led her team with 19 points, including six in the final 96 seconds as the Mustangs closed in but were unable to catch Smyer.
Emily Williams added 14 points and 12 rebounds, and Joanna Daniel notched 13 points.